Billions of COVID vaccine doses need to be produced. Contract manufacturing by third parties is critical, for large companies like Pfizer with mass production expertise and for smaller companies like Moderna with no production track record.
Companies are lining up to help. Sanofi and Novartis are helping Pfizer produce more doses. Contract manufacturers Catalent Pharma Solutions and Lonza are helping Moderna. Merck is helping Johnson & Johnson. But vaccine manufacturing is complex, especially for new gene-based mRNA technology in the Pfizer/Moderna vaccines. It’s hard to build from scratch, train employees, set up production lines, satisfy regulators so production can begin, then ramp up to warp speed. It’s easy to make mistakes so product specs aren’t met e.g. Emergent BioSolutions recently ruined 15M doses of the J&J vaccine.
For complex manufacturing, check out MOSIMTEC manufacturing modeling and simulation. Leverage the newest technology and explore options virtually to set up/test production lines, increase capacity, select equipment, allocate resources, schedule staff, set replenishment/reorder quantities for supplies, conduct batch sizing, testing and release variability analysis and more. See what works best for KPI’s before real world rollout.
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Read more here: https://www.wsj.com/articles/to-make-more-covid-19-vaccines-rival-drugmakers-team-up-11614081601